Systems and methods for determining at least one artifact calibration coefficient

ABSTRACT

A method for determining at least one artifact calibration coefficient is provided. The method may include obtaining preliminary projection values of a first object. The radiation rays may be detected by at least one radiation detector. The method may further include generating a preliminary image of the first object based on the preliminary projection values of the first object and generating calibrated projection values of the first object based on the preliminary image. The method may further include determining a relationship between the preliminary projection values and the calibrated projection values. The method may further include, for each of the at least one radiation detector, determining a location of the radiation detector and determining an artifact calibration coefficient corresponding to the radiation detector based on the relationship between the preliminary projection values and the calibrated projection values and the location of the radiation detector.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to Chinese Patent Application No.201711363321.8, filed on Dec. 18, 2017, and Chinese Patent ApplicationNo. 201711244741.4, filed on Nov. 30, 2017, the contents of each ofwhich are hereby incorporated by reference.

TECHNICAL FIELD

The present disclosure generally relates to imaging technology, and moreparticularly, relates to systems and methods for determining at leastone artifact calibration coefficient and reconstructing a correctedimage of an object based on the at least one artifact calibrationcoefficient.

BACKGROUND

Imaging technology has been widely used for clinical examination andmedical diagnosis. Artifacts may be present in a reconstructed image andmay greatly affect the quality of the reconstructed image. There arevarious types of artifacts, such as a streak artifact, a shadingartifact, a ring artifact, a banding artifact, etc. The ring artifact isoften caused by the inconsistent intensity responses of radiationdetectors and/or abnormal responses to radiation rays of differentenergy levels. For a reconstructed computed tomography (CT) image, thering artifact may significantly influence the measured result ofattenuation of the radiation rays that passed through a certain part ofan object (e.g., a patient, an organ, or tissue). Sometimes the ringartifact may influence the medical diagnosis. To reduce or eliminate thering artifacts, an artifact calibration coefficient corresponding toeach radiation detector is often used to generate a corrected image ofthe object. Many existing methods for reducing or eliminating the ringartifacts are not effective enough. Therefore, it is desirable toprovide systems and methods for determining the calibrationcoefficient(s) more accurately and more efficiently.

SUMMARY

According to a first aspect of the present disclosure, a method fordetermining at least one artifact calibration coefficient is provided.The method may be implemented on a computing device having at least onestorage device storing a set of instructions and at least one processorin communication with the at least one storage device. The method mayinclude obtaining, by the at least one processor, preliminary projectionvalues of a first object. The preliminary projection values may begenerated based on radiation rays that are emitted from a radiationemitter and passed through the first project. The radiation rays may bedetected by at least one radiation detector. The method may furtherinclude generating, by the at least one processor, a preliminary imageof the first object based on the preliminary projection values of thefirst object. The method may further include generating, by the at leastone processor, calibrated projection values of the first object based onthe preliminary image. The method may further include determining, bythe at least one processor, a relationship between the preliminaryprojection values and the calibrated projection values. The method mayfurther include, for each of the at least one radiation detector,determining, by the at least one processor, a location of the radiationdetector and determining, by the at least one processor, an artifactcalibration coefficient corresponding to the radiation detector based onthe relationship between the preliminary projection values and thecalibrated projection values and the location of the radiation detector.

In some embodiments, generating the calibrated projection values of thefirst object based on the preliminary image may include generating acalibrated image of the first object based on the preliminary image andgenerating the calibrated projection values based on the calibratedimage.

In some embodiments, the first object may be a phantom made of a singlematerial. Generating the calibrated image of the first object based onthe preliminary image may include obtaining a value of each of pixels inthe preliminary image, determining an average value of at least portionof the pixels in the preliminary image, and assigning the average valueof the at least portion of the pixels as a new value to the each of theat least portion of the pixels in the preliminary image to generate thecalibrated image.

In some embodiments, the first object may be a phantom including a bodymade of a first material and a shell made of a second material.Generating the calibrated image of the first object based on thepreliminary image may include obtaining a value of each of first pixelsin the preliminary image associated with the body of the first objectand a value of each of second pixels in the preliminary image associatedwith the shell of the first object. Generating the calibrated image ofthe first object based on the preliminary image may further includedetermining an average value of the first pixels, assigning the averagevalue of the first pixels as a new value to the each of the firstpixels, and retaining the value of the each of second pixels to generatethe calibrated image.

In some embodiments, generating the calibrated projection values basedon the calibrated image may include performing a forward projection onthe calibrated image to generate forward projection values, and for eachof the at least one radiation detector, determining a calibratedprojection value for the radiation detector based on the location of theradiation detector and the forward projection values.

In some embodiments, generating the calibrated projection values of thefirst object based on the preliminary image may include obtaining across-section equation of the first object based on the preliminaryimage of the first object and obtaining a series of scanning equations,wherein each of the series of scanning equations is associated with oneof the radiation rays. Generating the calibrated projection values ofthe first object based on the preliminary image may further includedetermining the calibrated projection values of the first object basedon the cross-section equation and the series of scanning equations ofthe first object.

In some embodiments, determining the calibrated projection values of thefirst object based on the cross-section equation and the series ofscanning equations of the first object may include, for each of theseries of scanning equations, determining, when there is no solutionsatisfying both the scanning equation and the cross-section equation,the calibrated projection value as zero; determining, when there is onlyone solution satisfying both the scanning equation and the cross-sectionequation, the calibrated projection value as zero; and determining, whenthere are two solutions satisfying both the scanning equation and thecross-section equation, the calibrated projection value based on thedistance between the two solutions.

In some embodiments, wherein the relationship between the preliminaryprojection values and the calibrated projection values is represented bya fitting curve.

In some embodiments, the method may further include performing apreprocessing on the preliminary projection values to generatepreprocessed projection value, and generating the preliminary imagebased on preprocessed projection values.

In some embodiments, the method may further include obtaining, by the atleast one processor, preliminary projection values of a second objectgenerated based on radiation rays that are emitted from the radiationemitter and passed through the second object. The radiation rays may bedetected by the at least one radiation detector. the method may furtherinclude determining corrected projection values of the second objectbased on the preliminary projection values of the second object and theat least one artifact calibration coefficient associated with the atleast one radiation detector, and generating a corrected image of thesecond object based on the corrected projection values.

According to another aspect of the present disclosure, a system fordetermining at least one artifact calibration coefficient is provided.The system may include at least one storage medium storing a set ofinstructions and at least one processor configured to communicate withthe at least one storage medium, wherein when executing the set ofinstructions, the at least one processor may be directed to cause thesystem to obtain preliminary projection values of a first objectgenerated based on radiation rays that are emitted from a radiationemitter and passed through the first project. The radiation rays may bedetected by at least one radiation detector. The least one processor maybe further directed to cause the system to generate a preliminary imageof the first object based on the preliminary projection values of thefirst object, generate calibrated projection values of the first objectbased on the preliminary image, and determine a relationship between thepreliminary projection values and the calibrated projection values. Theleast one processor may be further directed to cause the system to, foreach of the at least one radiation detector, determine a location of theradiation detector and determine an artifact calibration coefficientcorresponding to the radiation detector based on the relationshipbetween the preliminary projection values and the calibrated projectionvalues and the location of the radiation detector.

According to yet another aspect of the present disclosure, anon-transitory computer readable medium is provided. The non-transitorycomputer readable medium may include at least one set of instructionsfor determining at least one artifact calibration coefficient. Whenexecuted by at least one processor of a computer device, the at leastone set of instructions may direct the at least one processor to obtainpreliminary projection values of a first object generated based onradiation rays that are emitted from a radiation emitter and passedthrough the first project. The radiation rays may be detected by atleast one radiation detector. The at least one set of instructions mayfurther direct the at least one processor to generate a preliminaryimage of the first object based on the preliminary projection values ofthe first object, generate calibrated projection values of the firstobject based on the preliminary image, and determine a relationshipbetween the preliminary projection values and the calibrated projectionvalues. The at least one set of instructions may further direct the atleast one processor to, for each of the at least one radiation detector,determine a location of the radiation detector and determine an artifactcalibration coefficient corresponding to the radiation detector based onthe relationship between the preliminary projection values and thecalibrated projection values and the location of the radiation detector.

Additional features will be set forth in part in the description whichfollows, and in part will become apparent to those skilled in the artupon examination of the following and the accompanying drawings or maybe learned by production or operation of the examples. The features ofthe present disclosure may be realized and attained by practice or useof various aspects of the methodologies, instrumentalities andcombinations set forth in the detailed examples discussed below.

BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosure is further described in terms of exemplaryembodiments. These exemplary embodiments are described in detail withreference to the drawings. The drawings are not to scale. Theseembodiments are non-limiting exemplary embodiments, in which likereference numerals represent similar structures throughout the severalviews of the drawings, and wherein:

FIG. 1 is a schematic diagram illustrating an exemplary imaging systemaccording to some embodiments of the present disclosure;

FIG. 2 is a schematic diagram illustrating exemplary hardware and/orsoftware components of an exemplary computing device according to someembodiments of the present disclosure;

FIG. 3 is a schematic diagram illustrating exemplary hardware and/orsoftware components of an exemplary mobile device according to someembodiments of the present disclosure;

FIG. 4 is a block diagram illustrating an exemplary artifact correctiondevice according to some embodiments of the present disclosure;

FIG. 5 is a flowchart illustrating an exemplary process for determiningat least one artifact calibration coefficient according to someembodiments of the present disclosure;

FIG. 6 is a flowchart illustrating an exemplary process for determiningat least one artifact coefficient according to some embodiments of thepresent disclosure;

FIG. 7 is a flowchart illustrating an exemplary process for obtaining apreliminary image according to some embodiments of the presentdisclosure;

FIG. 8 is a flowchart illustrating an exemplary process for determiningcalibrated projection values based on a calibrated image according tosome embodiments of the present disclosure;

FIGS. 9A-9B are schematic diagrams illustrating exemplary phantomsaccording to some embodiments of the present disclosure;

FIG. 10 is a schematic diagram illustrating an exemplary fitting resultof the calibrated projection values and the preprocessed projectionvalues according to some embodiments of the present disclosure;

FIG. 11 is a flowchart illustrating an exemplary process forreconstructing a corrected image according to some embodiments of thepresent disclosure;

FIG. 12 is a flowchart illustrating an exemplary process for determiningat least one calibration coefficient and generating a calibration tableaccording to some embodiments of the present disclosure; and

FIG. 13 is a schematic diagram illustrating an exemplary scan on anobject according to some embodiments of the present disclosure.

DETAILED DESCRIPTION

In the following detailed description, numerous specific details are setforth by way of examples in order to provide a thorough understanding ofthe relevant disclosure. However, it should be apparent to those skilledin the art that the present disclosure may be practiced without suchdetails. In other instances, well-known methods, procedures, systems,components, and/or circuitry have been described at a relativelyhigh-level, without detail, in order to avoid unnecessarily obscuringaspects of the present disclosure. Various modifications to thedisclosed embodiments will be readily apparent to those skilled in theart, and the general principles defined herein may be applied to otherembodiments and applications without departing from the spirit and scopeof the present disclosure. Thus, the present disclosure is not limitedto the embodiments shown, but to be accorded the widest scope consistentwith the claims.

The terminology used herein is for the purpose of describing particularexample embodiments only and is not intended to be limiting. As usedherein, the singular forms “a,” “an,” and “the” may be intended toinclude the plural forms as well, unless the context clearly indicatesotherwise. It will be further understood that the terms “comprise,”“comprises,” and/or “comprising,” “include,” “includes,” and/or“including,” when used in this specification, specify the presence ofstated features, integers, steps, operations, elements, and/orcomponents, but do not preclude the presence or addition of one or moreother features, integers, steps, operations, elements, components,and/or groups thereof.

It will be understood that the term “system,” “engine,” “unit,”“module,” and/or “block” used herein are one method to distinguishdifferent components, elements, parts, section or assembly of differentlevel in ascending order. However, the terms may be displaced by otherexpression if they achieve the same purpose.

Generally, the word “module,” “unit,” or “block,” as used herein, refersto logic embodied in hardware or firmware, or to a collection ofsoftware instructions. A module, a unit, or a block described herein maybe implemented as software and/or hardware and may be stored in any typeof non-transitory computer-readable medium or other storage device. Insome embodiments, a software module/unit/block may be compiled andlinked into an executable program. It will be appreciated that softwaremodules can be callable from other modules/units/blocks or fromthemselves, and/or may be invoked in response to detected events orinterrupts. Software modules/units/blocks configured for execution oncomputing devices (e.g., processor 210 as illustrated in FIG. 2) may beprovided on a computer-readable medium, such as a compact disc, adigital video disc, a flash drive, a magnetic disc, or any othertangible medium, or as a digital download (and can be originally storedin a compressed or installable format that needs installation,decompression, or decryption prior to execution). Such software code maybe stored, partially or fully, on a storage device of the executingcomputing device, for execution by the computing device. Softwareinstructions may be embedded in a firmware, such as an EPROM. It will befurther appreciated that hardware modules/units/blocks may be includedin connected logic components, such as gates and flip-flops, and/or canbe included of programmable units, such as programmable gate arrays orprocessors. The modules/units/blocks or computing device functionalitydescribed herein may be implemented as software modules/units/blocks,but may be represented in hardware or firmware. In general, themodules/units/blocks described herein refer to logicalmodules/units/blocks that may be combined with othermodules/units/blocks or divided into sub-modules/sub-units/sub-blocksdespite their physical organization or storage. The description may beapplicable to a system, an engine, or a portion thereof.

It will be understood that when a unit, engine, module or block isreferred to as being “on,” “connected to,” or “coupled to,” anotherunit, engine, module, or block, it may be directly on, connected orcoupled to, or communicate with the other unit, engine, module, orblock, or an intervening unit, engine, module, or block may be present,unless the context clearly indicates otherwise. As used herein, the term“and/or” includes any and all combinations of one or more of theassociated listed items.

These and other features, and characteristics of the present disclosure,as well as the methods of operation and functions of the relatedelements of structure and the combination of parts and economies ofmanufacture, may become more apparent upon consideration of thefollowing description with reference to the accompanying drawings, allof which form a part of this disclosure. It is to be expresslyunderstood, however, that the drawings are for the purpose ofillustration and description only and are not intended to limit thescope of the present disclosure. It is understood that the drawings arenot to scale.

Provided herein are systems and components for an imaging system. Insome embodiments, the imaging system may include a single modalityimaging system and/or a multi-modality imaging system. The singlemodality imaging system may include, for example, an X-ray imagingsystem, an computed tomography (CT) system, a magnetic resonance imaging(MRI) system, an ultrasonography system, a positron emission tomography(PET) system, or the like, or any combination thereof. Themulti-modality imaging system may include, for example, an X-rayimaging-magnetic resonance imaging (X-ray-MRI) system, a positronemission tomography-X-ray imaging (PET-X-ray) system, a single photonemission computed tomography-magnetic resonance imaging (SPECT-MRI)system, a positron emission tomography-computed tomography (PET-CT)system, a C-arm system, a digital subtraction angiography-magneticresonance imaging (DSA-MRI) system, etc. It should be noted that theimaging system described below is merely provided for illustrationpurposes, and not intended to limit the scope of the present disclosure.

The present disclosure provides mechanisms (which can include methods,systems, computer-readable medium, etc.) for determining at least oneartifact calibration coefficient. An imaging device may perform one ormore scans on a first object (e.g., a phantom) to obtain preliminaryprojection values of the first object. A preliminary image of the firstobject may be generated based on the preliminary projection values ofthe first object. In some embodiments, a calibrated image of the firstobject may be generated based on the preliminary image and calibratedprojection values may be generated based on the calibrated image. Insome embodiments, the calibrated projection values may be determinedbased on a cross-section equation of the first object and a series ofscanning equations associated with radiation rays emitted from aradiation emitter and detected by at least one radiation detector of theimaging device. For each of the at least one radiation detector of theimaging device, one or more preliminary projection values and one ormore corresponding calibrated projection values related to the radiationdetector may be determined. A calibration coefficient may be determinedfor each of the at least one radiation detector based on the one or morepreliminary projection values and the one or more correspondingcalibrated projection values related to the radiation detector, forexample, using a fitting algorithm. The calibration coefficient(s) ofthe at least one radiation detector may be used to correct thepreliminary projection values of a second object (e.g., a patient, anorgan, or tissue) to reduce or eliminate artifacts associated with theat least one radiation detector.

FIG. 1 is a schematic diagram illustrating an exemplary imaging system100 according to some embodiments of the present disclosure. In someembodiments, the imaging system 100 may scan an object to obtainpreliminary projection values and generate an image associated with theobject. In some embodiments, the imaging system 100 may be a medicalimaging system, for example, a Positron Emission Tomography (PET)device, a Computed Tomography (CT) device, a Magnetic resonance imagingdevice (MRI), or the like. In some embodiments, the imaging system 100may include an imaging device, a computing device 140, an imagegenerator 150, and a displaying device 160.

The imaging device may generate or provide image data via scanning anobject (e.g., a patient) disposed on a scanning table of the imagingdevice. In some embodiments, the imaging device may include asingle-modality scanner and/or multi-modality scanner. Thesingle-modality scanner may include, for example, a computed tomography(CT) scanner. The multi-modality scanner may include a single photonemission computed tomography-computed tomography (SPECT-CT) scanner, apositron emission tomography-computed tomography (PET-CT) scanner, acomputed tomography-ultra-sonic (CT-US) scanner, a digital subtractionangiography-computed tomography (DSA-CT) scanner, or the like, or acombination thereof. In some embodiments, the image data may includeprojection data, images relating to the object, etc. The projection datamay be raw data generated by the imaging device by scanning the objector data generated by a forward projection on an image relating to theobject. In some embodiments, the object may include a body, a substance,an object, or the like, or a combination thereof. In some embodiments,the object may include a specific portion of a body, such as a head, athorax, an abdomen, or the like, or a combination thereof. In someembodiments, the object may include a specific organ or region ofinterest, such as an esophagus, a trachea, a bronchus, a stomach, agallbladder, a small intestine, a colon, a bladder, a ureter, a uterus,a fallopian tube, etc.

As shown in FIG. 1, the imaging device may include a scanning cavity110, a scanning table 120, and a high voltage generator 130. Thescanning cavity 110 may contain components for generating and detectingradioactive rays. In some embodiments, the scanning cavity 110 maycontain a radiation generator 180 and a radiation detector 170. Theradiation generator 180 may emit radioactive rays. The radioactive raysmay be emitted toward an object placed in the scanning cavity 110 andmay pass through the object and be received by the radiation detector170. As an example, the radiation generator 180 may be an X-ray tube.The X-ray tube may emit X-rays that pass through an object placed insidethe scanning cavity 110 and may be received by the radiation detector170. In some embodiments, the radiation detector 170 may be a circularradiation detector, a square radiation detector, an arc radiationdetector, a planar radiation detector, or the like. In some embodiments,there may be multiple radiation detectors 170 (also referred to asdetector units). The scanning table 120 may support an object to bedetected (e.g., a patient, a phantom, etc.). In some embodiments, thescanning table 120 may move inside the scanning cavity 110 during thedetection process. As shown in FIG. 1, the scanning table 120 may movealong the Z-axis direction before, during or after a scan. Depending onthe needs of the test, the patient may be supine, prone, with the headin the front or foot. In some embodiments, the scanning table 120 maymove inside the scanning cavity 110 at a constant speed. The speed atwhich the scanning table 120 moves may be related to factors such asscanning time, a scanning region, or the like, or any combinationthereof. In some embodiments, the speed at which the scanning table 120moves may be the system default value, and may also be set by the user.The high voltage generator 130 may generate a high voltage or a strongcurrent. In some embodiments, the generated high voltage or strongcurrent may be transmitted to the radiation generator 180.

In some embodiments, the imaging device may be integrated with one ormore other devices that may facilitate the scanning of the object, suchas, an image-recording device. The image-recording device may beconfigured to take various types of images related to the object. Forexample, the image-recording device may be a two-dimensional (2D) camerathat takes pictures of the exterior or outline of the object. As anotherexample, the image-recording device may be a 3D scanner (e.g., a laserscanner, an infrared scanner, a 3D CMOS sensor) that records the spatialrepresentation of the object.

In some embodiments, the computing device 140 may control the scanningcavity 110 to rotate to a certain position. This location may be adefault value of the imaging system 100, and may also be set by the user(e.g., a doctor, a nurse). In some embodiments, the computing device 140may control the high voltage generator 130. For example, the computingdevice 140 may control the intensity of the voltage or current generatedby the high voltage generator 130. In some embodiments, the computingdevice 140 may control the displaying device 160. For example, thecomputing device 140 may control and display relevant parameters. Theparameters may include display size, display scale, display order,display quantity, or the like, or any combination thereof. The computingdevice 140 may process data and/or information obtained from the imagingdevice, the storage device, the terminal(s), or other components of theimaging system 100. For example, the computing device 140 mayreconstruct an image based on projection data generated by the imagingdevice. As another example, the computing device 140 may determine theposition of a target region (e.g., a region in a patient) to be scannedby the imaging device. In some embodiments, the computing device 140 maybe a single server or a server group. The server group may becentralized or distributed. In some embodiments, the computing device140 may be local to or remote from the imaging system 100. For example,the computing device 140 may access information and/or data from theimaging device, the storage device, and/or the terminal(s) via thenetwork. As another example, the computing device 140 may be directlyconnected to the imaging device, the terminal(s), and/or the storagedevice to access information and/or data. In some embodiments, thecomputing device 140 may be implemented on a cloud platform. Forexample, the cloud platform may include a private cloud, a public cloud,a hybrid cloud, a community cloud, a distributed cloud, an inter-cloud,a multi-cloud, or the like, or a combination thereof. In someembodiments, the computing device 140 may be implemented by a computingdevice 140 having one or more components as described in connection withFIG. 2.

The storage device may store data, instructions, and/or any otherinformation. In some embodiments, the storage device may store dataobtained from the computing device 140, the terminal(s), and/or theinteraction device 150. In some embodiments, the storage device maystore data and/or instructions that the computing device 140 may executeor use to perform exemplary methods described in the present disclosure.In some embodiments, the storage device may include a mass storage, aremovable storage, a volatile read-and-write memory, a read-only memory(ROM), or the like, or any combination thereof. Exemplary mass storagemay include a magnetic disk, an optical disk, a solid-state drive, etc.Exemplary removable storage may include a flash drive, a floppy disk, anoptical disk, a memory card, a zip disk, a magnetic tape, etc. Exemplaryvolatile read-and-write memory may include a random access memory (RAM).Exemplary RAM may include a dynamic RAM (DRAM), a double date ratesynchronous dynamic RAM (DDR SDRAM), a static RAM (SRAM), a thyristorRAM (T-RAM), and a zero-capacitor RAM (Z-RAM), etc. Exemplary ROM mayinclude a mask ROM (MROM), a programmable ROM (PROM), an erasableprogrammable ROM (EPROM), an electrically erasable programmable ROM(EEPROM), a compact disk ROM (CD-ROM), and a digital versatile disk ROM,etc. In some embodiments, the storage device may be implemented on acloud platform as described elsewhere in the disclosure. One or morecomponents of the imaging system 100 may access the data or instructionsstored in the storage device via the network. In some embodiments, thestorage device may be part of the computing device 140.

The image generator 150 may generate an image. In some embodiments, theimage generator 150 may perform operations such as image preprocessing,image reconstruction, and/or artifact correction. In some embodiments,the image generator 150 may be integrated in the computing device 140.In some embodiments, the image generator 150 may receive data from theradiation detector(s) 170 or an external data source and generate animage based on the received data. In some embodiments, the imagegenerator 150 may transmit the generated image to the displaying device160 for display.

The displaying device 160 may display the received data or image. Insome embodiments, the displaying device 160 may display an imagegenerated by the image generator 150. In some embodiments, thedisplaying device 160 may be a terminal including input devices. A usermay send an instruction to the image generator 150 and/or the computingdevice 140 via the displaying device 160. For example, the user may setimaging parameters through displaying device 160, which may be sent tocomputing device 140. The imaging parameters may include dataacquisition parameters and image reconstruction parameters, and thelike. For example, the terminal(s) may obtain a processed image from thecomputing device 140. As another example, the terminal(s) may obtainimage data acquired via the imaging device and transmit the image datato the computing device 140 to be processed. In some embodiments, theterminal(s) may include a mobile device, a tablet computer, a laptopcomputer, or the like, or any combination thereof. For example, themobile device may include a mobile phone, a personal digital assistance(PDA), a gaming device, a navigation device, a point of sale (POS)device, a laptop, a tablet computer, a desktop, or the like, or anycombination thereof. In some embodiments, the terminal(s) may include aninput device, an output device, etc. The input device may includealphanumeric and other keys that may be input via a keyboard, a touchscreen (for example, with haptics or tactile feedback), a speech input,an eye tracking input, a brain monitoring system, or any othercomparable input mechanism. The input information received through theinput device may be transmitted to the computing device 140 via, forexample, a bus, for further processing. Other types of the input devicemay include a cursor control device, such as a mouse, a trackball, orcursor direction keys, etc. The output device may include a display, aspeaker, a printer, or the like, or a combination thereof. In someembodiments, the terminal(s) may be part of the computing device 140.

The computing device 140, the scanning cavity 110, the radiationgenerator 180, the radiation detector 170, the high voltage generator130, the scanning table 120, the image generator 150, and/or thedisplaying device 160 may be connected indirectly by direct or indirectmeans. For example, these devices of the imaging system 100 may beconnected to and/or communicate with each other via a wirelessconnection (e.g., a network), a wired connection, or a combinationthereof. The connection between the components of the imaging system 100may be variable. The network may include any suitable network that canfacilitate exchange of information and/or data for the imaging system100. For example, the network may be or include a public network (e.g.,the Internet), a private network (e.g., a local area network (LAN)), awired network, a wireless network (e.g., an 802.11 network, a Wi-Finetwork), a frame relay network, a virtual private network (VPN), asatellite network, a telephone network, routers, hubs, switches, servercomputers, and/or any combination thereof. For example, the network mayinclude a cable network, a wireline network, a fiber-optic network, atelecommunications network, an intranet, a wireless local area network(WLAN), a metropolitan area network (MAN), a public telephone switchednetwork (PSTN), a Bluetooth™ network, a ZigBee™ network, a near fieldcommunication (NFC) network, or the like, or any combination thereof. Insome embodiments, the network may include one or more network accesspoints. For example, the network may include wired and/or wirelessnetwork access points such as base stations and/or internet exchangepoints through which one or more components of the imaging system 100may be connected to the network to exchange data and/or information.

This description is intended to be illustrative, and not to limit thescope of the present disclosure. Many alternatives, modifications, andvariations will be apparent to those skilled in the art. The features,structures, methods, and other characteristics of the exemplaryembodiments described herein may be combined in various ways to obtainadditional and/or alternative exemplary embodiments. For example, thestorage device may be a data storage including cloud computingplatforms, such as public cloud, private cloud, community, and hybridclouds, etc. However, those variations and modifications do not departthe scope of the present disclosure.

FIG. 2 is a schematic diagram illustrating exemplary hardware and/orsoftware components of an exemplary computing device 140 on which thecomputing device 140 may be implemented according to some embodiments ofthe present disclosure. As illustrated in FIG. 2, the computing device140 may include a processor 210, a storage 220, an input/output (I/O)230, and a communication port 240.

The processor 210 may execute computer instructions (e.g., program code)and perform functions of the computing device 140 in accordance withtechniques described herein. The computer instructions may include, forexample, routines, programs, objects, components, data structures,procedures, modules, and functions, which perform particular functionsdescribed herein. For example, the processor 210 may process image dataobtained from the imaging device, the terminals, the storage device,and/or any other component of the imaging system 100. In someembodiments, the processor 210 may include one or more hardwareprocessors, such as a microcontroller, a microprocessor, a reducedinstruction set computer (RISC), an application specific integratedcircuits (ASICs), an application-specific instruction-set processor(ASIP), a central processing unit (CPU), a graphics processing unit(GPU), a physics processing unit (PPU), a microcontroller unit, adigital signal processor (DSP), a field programmable gate array (FPGA),an advanced RISC machine (ARM), a programmable logic device (PLD), anycircuit or processor capable of executing one or more functions, or thelike, or any combinations thereof.

Merely for illustration, only one processor is described in thecomputing device 140. However, it should be noted that the computingdevice 140 in the present disclosure may also include multipleprocessors, thus operations and/or method operations that are performedby one processor as described in the present disclosure may also bejointly or separately performed by the multiple processors. For example,if in the present disclosure the processor of the computing device 140executes both operation A and operation B, it should be understood thatoperation A and operation B may also be performed by two or moredifferent processors jointly or separately in the computing device 140(e.g., a first processor executes operation A and a second processorexecutes operation B, or the first and second processors jointly executeoperation s A and B).

The storage 220 may store data/information obtained from the imagingdevice, the terminals, the storage device, and/or any other component ofthe imaging system 100. In some embodiments, the storage 220 may includea mass storage, a removable storage, a volatile read-and-write memory, aread-only memory (ROM), or the like, or any combination thereof. Forexample, the mass storage may include a magnetic disk, an optical disk,a solid-state drives, etc. The removable storage may include a flashdrive, a floppy disk, an optical disk, a memory card, a zip disk, amagnetic tape, etc. The volatile read-and-write memory may include arandom access memory (RAM). The RAM may include a dynamic RAM (DRAM), adouble date rate synchronous dynamic RAM (DDR SDRAM), a static RAM(SRAM), a thyristor RAM (T-RAM), and a zero-capacitor RAM (Z-RAM), etc.The ROM may include a mask ROM (MROM), a programmable ROM (PROM), anerasable programmable ROM (EPROM), an electrically erasable programmableROM (EEPROM), a compact disk ROM (CD-ROM), and a digital versatile diskROM, etc. In some embodiments, the storage 220 may store one or moreprograms and/or instructions to perform exemplary methods described inthe present disclosure. For example, the storage 220 may store a programfor the computing device 140 for determining the position of a targetregion of an object (e.g., a target portion of a patient).

The I/O 230 may input and/or output signals, data, information, etc. Insome embodiments, the I/O 230 may enable a user interaction with thecomputing device 140. In some embodiments, the I/O 230 may include aninput device and an output device. Examples of the input device mayinclude a keyboard, a mouse, a touch screen, a microphone, or the like,or a combination thereof. Examples of the output device may include adisplay device, a loudspeaker, a printer, a projector, or the like, or acombination thereof. Examples of the display device may include a liquidcrystal display (LCD), a light-emitting diode (LED)-based display, aflat panel display, a curved screen, a television device, a cathode raytube (CRT), a touch screen, or the like, or a combination thereof.

The communication port 240 may be connected to a network (e.g., thenetwork) to facilitate data communications. The communication port 240may establish connections between the computing device 140 and theimaging device, the terminals, and/or the storage device. The connectionmay be a wired connection, a wireless connection, any othercommunication connection that can enable data transmission and/orreception, and/or any combination of these connections. The wiredconnection may include, for example, an electrical cable, an opticalcable, a telephone wire, or the like, or any combination thereof. Thewireless connection may include, for example, a Bluetooth™ link, aWi-Fi™ link, a WiMax™ link, a WLAN link, a ZigBee™ link, a mobilenetwork link (e.g., 3G, 4G, 5G), or the like, or a combination thereof.In some embodiments, the communication port 240 may be and/or include astandardized communication port, such as RS232, RS485, etc. In someembodiments, the communication port 240 may be a specially designedcommunication port. For example, the communication port 240 may bedesigned in accordance with the digital imaging and communications inmedicine (DICOM) protocol.

FIG. 3 is a schematic diagram illustrating exemplary hardware and/orsoftware components of an exemplary mobile device 300 on which theterminals may be implemented according to some embodiments of thepresent disclosure. As illustrated in FIG. 3, the mobile device 300 mayinclude a communication platform 310, a display 320, a graphicprocessing unit (GPU) 330, a central processing unit (CPU) 340, an I/O350, a memory 360, and a storage 390. In some embodiments, any othersuitable component, including but not limited to a system bus or acontroller (not shown), may also be included in the mobile device 300.In some embodiments, a mobile operating system 370 (e.g., iOS™,Android™, Windows Phone™) and one or more applications 380 may be loadedinto the memory 360 from the storage 390 in order to be executed by theCPU 340. The applications 380 may include a browser or any othersuitable mobile apps for receiving and rendering information relating toimage processing or other information from the computing device 140.User interactions with the information stream may be achieved via theI/O 350 and provided to the computing device 140 and/or other componentsof the imaging system 100 via the network.

To implement various modules, units, and their functionalities describedin the present disclosure, computer hardware platforms may be used asthe hardware platform(s) for one or more of the elements describedherein. A computer with user interface elements may be used to implementa personal computer (PC) or any other type of work station or terminaldevice. A computer may also act as a server if appropriately programmed.

FIG. 4 is a block diagram illustrating an exemplary artifact correctiondevice 400 according to some embodiments of the present disclosure. Insome embodiments, the artifact correction device 400 may be implementedas a processor (e.g., the processor 210 of the computing device 140). Asillustrated in FIG. 4, the artifact correction device 400 may include adata reception module 410, a preprocessing module 420, a calibrationmodule 430, a reconstruction module 440, and a storage module 450. Themodules may be hardware circuits of all or part of the artifactcorrection device 400. The modules may also be implemented as anapplication or set of instructions read and executed by the artifactcorrection device 400. Further, the modules may be any combination ofthe hardware circuits and the application/instructions. For example, themodules may be the part of the artifact correction device 400 when theartifact correction device 400 is executing the application/set ofinstructions.

The data reception module 410 may obtain and/or receive data related tothe imaging system 100. In some embodiments, the data reception module410 may obtain and/or receive data from one or more components of theimaging system 100. For example, the data reception module 410 mayreceive data related to an object. The data related to the object mayinclude preliminary projection values of the object, preliminaryinformation of the object (e.g., the name, the age, the gender, theheight, or the weight), scanning parameters, or the like, or anycombination thereof. The data reception module 410 may receive thepreliminary projection values or preliminary projection data of a firstobject from an imaging device (e.g., a CT scanner, an MRI scanner, or aPET scanner) and/or a storage (e.g., the storage 220 of the computingdevice 140). In some embodiments, the data reception module 410 mayobtain at least one calibration coefficient corresponding to the atleast one radiation detector from the storage.

The preprocessing module 420 may preprocess data related to the imagingsystem 100. In some embodiments, the preprocessing module 420 maypreprocess the preliminary projection values of the object to obtainpreprocessed projection values. The preprocessing operation mayeliminate or reduce the error caused by known physical factors on thepreliminary projection values. For example, the preprocessing operationmay include air correction, crosstalk correction, off-focal correction,beam hardening correction, or the like, or any combination thereof.

The calibration module 430 may generate calibrated projection values ofan object. In some embodiments, the calibration module 430 may generatea calibrated image of the first object based on the preliminary imageand generate the calibrated projection values based on the calibratedimage. For example, when the first object is a uniform phantom made of asingle material, the calibration module 430 may classify the pixels inthe preliminary image into material pixels of the phantom body (pixelscorresponding to at least a part of the phantom) and air pixels (pixelscorresponding to air inside and/or around the phantom) using a thresholdmethod and/or an image segmentation algorithm. The calibration module430 may obtain a value of each of the material pixels of the phantombody and determine an average value of the material pixels of thephantom body. To generate the calibrated image, the average value of thematerial pixels of the phantom body may be assigned to each of thematerial pixels of the phantom body in the preliminary image as a newvalue and the value of each of the air pixels may be set as 0. Asanother example, when the first object is a phantom having a body madeof a first material and a shell made of a second material, thecalibration module 430 may classify the pixels in the preliminary imageinto material pixels of the phantom body (also referred to as firstpixels), material pixels of the phantom shell (also referred to assecond pixels), and air pixels. The calibration module 430 may obtain avalue of each of the first pixels in the preliminary image and a valueof each of the second pixels in the preliminary image. An average valuemay be determined for the first pixels. To generate the calibratedimage, the average value of the first pixels may be assigned as a newvalue to each of the first pixels, the value of each of the secondpixels may be retained unchanged, and the value of each of the airpixels may be set as 0. The calibration module 430 may further perform aforward projection (e.g., an equal-spaced parallel beam projection) onthe calibrated image to generate the calibrated projection values.

In some embodiments, the calibration module 430 may obtain across-section equation of the first object based on the preliminaryimage of the first object. Merely by way of example, the cross sectionof the first object may be an ellipse. The calibration module 430 mayobtain a series of scanning equations (e.g., straight line equations),where each of the series of scanning equations may be associated with aradiation ray emitted from the radiation emitter. The calibration module430 may further determine the calibrated projection values based on thecross-section equation and the series of scanning equations. Forinstance, for each of the series of scanning equations, the calibrationmodule 430 may determine whether there is a solution satisfying both thecross-section equation and the scanning equation. In response to adetermination that there is no solution or only one solution satisfyingboth the cross-section equation and the scanning equation, thecalibrated projection value corresponding to the radiation ray may bedetermined as 0. In response to a determination that there are twosolutions satisfying both the cross-section equation and the scanningequation, the calibrated projection value corresponding to the radiationray may be determined based on the distance between the two solutions(e.g., intersection points).

In some embodiments, the calibration module 430 may determine at leastone calibration coefficient corresponding to the at least one radiationdetector based on the preprocessed projection values (or the preliminaryprojection values) and the calibrated projection values of the firstobject. In some embodiments, the artifact correction device 400 mayfurther include a correction module (not shown in FIG. 4). Thecorrection module may determine corrected projection values of a secondobject (e.g., a patient) based on the at least one calibrationcoefficient and preprocessed projection values (or the preliminaryprojection values) of the second object.

The reconstruction module 440 may reconstruct an image. In someembodiments, the reconstruction module 440 may generate a preliminaryimage of the first object based on the preliminary projection values orthe preprocessed projection values of the first object using an imagingreconstruction algorithm. In some embodiments, the reconstruction module440 may generate a corrected image of the second object (e.g., apatient) based on the corrected projection values of the second object.An exemplary imaging reconstruction algorithm may include an iterativealgorithm, a filtered back projection algorithm, a Radon transformalgorithm, a direct Fourier algorithm, or the like, or any combinationthereof.

The storage module 450 may store information related to the imagingsystem 100. In some embodiments, the storage module 450 may store acalibration table. The calibration table may include the at least onecalibration coefficient corresponding to the at least one radiationdetector. In some embodiments, the storage module 450 may store thepreliminary projection values of an object, the preliminary informationof the object, scanning parameters, or the like, or any combinationthereof. In some embodiments, the storage module 450 may store anreconstructed image (e.g., a corrected image of a second object).

It should be noted that the above description is merely provided for thepurposes of illustration, and not intended to limit the scope of thepresent disclosure. For persons having ordinary skills in the art,multiple variations or modifications may be made under the teachings ofthe present disclosure. However, those variations and modifications donot depart from the scope of the present disclosure. In someembodiments, the artifact correction device 400 may include one or moreadditional modules. For example, the artifact correction device 400 mayfurther include a control module configured to generate control signalsfor one or more components in the imaging system 100.

FIG. 5 is a flowchart illustrating an exemplary process for determiningat least one artifact calibration coefficient according to someembodiments of the present disclosure. At least a portion of process 500may be implemented on the computing device 140 as illustrated in FIG. 2or the mobile device 300 as illustrated in FIG. 3. In some embodiments,one or more operations of the process 500 may be implemented in theimaging system 100 as illustrated in FIG. 1. In some embodiments, one ormore operations in the process 500 may be stored in the storage (e.g.,the ROM 230, the RAM 240) as a form of instructions, and invoked and/orexecuted by the computing device 140 (e.g., the processor 210 of thecomputing device 140). In some embodiments, the instructions may betransmitted in a form of electronic current or electrical signals.

In 502, the processor 210 (e.g., the data reception module 410) mayobtain preliminary projection values of a first object generated basedon radiation rays that are emitted from a radiation emitter and passedthrough the first object, where the radiation rays are detected by atleast one radiation detector. In some embodiments, the first object mayinclude a phantom. As used herein, the term “phantom” (also referred toas “imaging phantom”) refers to a specially designed object to evaluate,analyze, and tune the performance of various imaging devices. Forexample, the phantom may be a uniform phantom made of a single material.As another example, the phantom may include a body made of a firstmaterial and a shell made of a second material. In some embodiments, theshape of the phantom may include but not limited to a cylinder, asphere, a cube, a simulation shape of a human body or a part thereof(e.g., a whole body, a head, a lung, an abdomen), or the like. In someembodiments, the phantom may be made of teflon, propylene, polyethylene,resin, or the like, or any combination thereof. The imaging device mayperform at least one scan on the first object placed at one or morepositions on the scanning table 120. The at least one radiation detectormay receive the radiation rays that passed through the first object andgenerate preliminary projection values of the first object. In someembodiments, the preliminary projection values may be determined basedon the intensity distribution of the energy of the radiation beamsemitted from the radiation emitter and the intensity distribution of theenergy of the radiation beams detected by the plurality of detectorelements (e.g., the preliminary projection values).

In 504, the processor 210 (e.g., the reconstruction module 440) maygenerate a preliminary image of the first object based on thepreliminary projection values of the first object. In some embodiments,the processor 210 may preprocess (or pre-correct) the preliminaryprojection values to generate preprocessed projection values. Thepreprocessing may eliminate or reduce the influence of known physicalfactors (e.g., detector gain, beam hardening) on the preliminaryprojection values. For example, the preprocessing may include aircorrection, crosstalk correction, off-focal correction, beam hardeningcorrection, or the like, or any combination thereof. In someembodiments, the processor 210 may reconstruct the preliminary image ofthe first object based on the preprocessed projection values using animage reconstruction algorithm. Exemplary imaging reconstructionalgorithms may include an iterative algorithm, a filtered backprojection algorithm, a Radon transform algorithm, a direct Fourieralgorithm, or the like, or any combination thereof. In some embodiments,there may be one or more artifacts in the preliminary image of the firstobject. The one or more artifacts may include a streak artifact, ashading artifact, a ring artifact, a banding artifact, or the like, orany combination thereof.

In 506, the processor 210 (e.g., the calibration module 430) maygenerate calibrated projection values of the first object based on thepreliminary image. In some embodiments, the processor 210 may generate acalibrated image of the first object based on the preliminary image andgenerate the calibrated projection values based on the calibrated image.For example, when the first object is a uniform phantom made of a singlematerial, the processor 210 may classify the pixels in the preliminaryimage into material pixels of the phantom body (pixels corresponding toat least a part of the phantom) and air pixels (pixels corresponding toair inside and/or around the phantom) using a threshold method and/or animage segmentation algorithm. The processor 210 may obtain a value ofeach of the material pixels of the phantom body and determine an averagevalue of the material pixels of the phantom body. To generate thecalibrated image, the average value of the material pixels of thephantom body may be assigned to each of the material pixels of thephantom body in the preliminary image as a new value and the value ofeach of the air pixels may be set as 0. As another example, when thefirst object is a phantom having a body made of a first material and ashell made of a second material, the processor 210 may classify thepixels in the preliminary image into material pixels of the phantom body(also referred to as first pixels), material pixels of the phantom shell(also referred to as second pixels), and air pixels. The processor 210may obtain a value of each of the first pixels in the preliminary imageand a value of each of the second pixels in the preliminary image. Anaverage value may be determined for the first pixels. To generate thecalibrated image, the average value of the first pixels may be assignedas a new value to each of the first pixels, the value of each of thesecond pixels may be retained unchanged, and the value of each of theair pixels may be set as 0. The processor 210 may further perform aforward projection (e.g., an equal-spaced parallel beam projection) onthe calibrated image to generate the calibrated projection values.

In some embodiments, the processor 210 may obtain a cross-sectionequation of the first object based on the preliminary image of the firstobject. Merely by way of example, the cross section of the first objectmay be an ellipse. The processor 210 may obtain a series of scanningequations (e.g., straight line equations), where each of the series ofscanning equations may be associated with a radiation ray emitted fromthe radiation emitter. The processor 210 may further determine thecalibrated projection values based on the cross-section equation and theseries of scanning equations. For instance, for each of the series ofscanning equations, the processor 210 may determine whether there is asolution satisfying both the cross-section equation and the scanningequation. In response to a determination that there is no solution oronly one solution satisfying both the cross-section equation and thescanning equation, the calibrated projection value corresponding to theradiation ray may be determined as 0. In response to a determinationthat there are two solutions satisfying both the cross-section equationand the scanning equation, the calibrated projection value correspondingto the radiation ray may be determined based on the distance between thetwo solutions (e.g., intersection points). More details regarding thedetermination of the calibrated projection values may be found elsewherein the present disclosure, for example, in FIG. 8, FIG. 12, and thedescriptions thereof.

In 508, the processor 210 (e.g., the calibration module 430) maydetermine a relationship between the preliminary projection values andthe calibrated projection values. For example, the processor 210 maydetermine a plurality of data groups, where each of the plurality ofdata group may include a preliminary projection value and acorresponding calibrated projection value.

In 510, for each of the at least one radiation detector, the processor210 (e.g., the calibration module 430) may determine a location of theradiation detector. In some embodiments, the processor 210 may determinethe location of the radiation detector based on the rotation of thegantry and the relative location between the radiation detector and thegantry. In some embodiments, the processor 210 may determine thelocation of the radiation detector in a coordinate system (e.g., thecoordinate system shown in FIG. 1).

In 512, for each of the at least one radiation detector, the processor210 (e.g., the calibration module 430) may determine an artifactcalibration coefficient corresponding to the radiation detector based onthe location of the radiation detector and the relationship between thepreliminary projection values and the calibrated projection values. Insome embodiments, for each of the at least one radiation detector, theprocessor 210 may perform an interpolation to determine a calibratedprojection value associated with the radiation detector. The calibratedprojection value associated with the radiation detector may bedetermined based on the location of the radiation detector and theforward projection values generated based on the calibrated image. Insome embodiments, the processor 210 may obtain the artifact calibrationcoefficient using a polynomial fitting algorithm, a cosine fittingalgorithm, a Gaussian fitting algorithm, a least square fittingalgorithm, or the like, or any combination thereof. In some embodiments,the processor 210 may generate a calibration table including theartifact calibration coefficient corresponding to each of the at leastone radiation detector. The calibration table may be stored in a storage(e.g., the ROM 230, the RAM 240 of the computing device) and/or anexternal storage device. In some embodiments, the processor 210 mayobtain preliminary projection values of a second object (e.g., apatient) and correct the preliminary projection values according to thecalibration table. Details regarding the correction of the preliminaryprojection values of the second object may be found elsewhere in thepresent disclosure, for example, in FIG. 11 and the descriptionsthereof.

It should be noted that the above description regarding the process 500is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure.

FIG. 6 is a flowchart illustrating an exemplary process for determiningat least one artifact coefficient according to some embodiments of thepresent disclosure. At least a portion of process 600 may be implementedon the computing device 140 as illustrated in FIG. 2 or the mobiledevice 300 as illustrated in FIG. 3. In some embodiments, one or moreoperations of the process 600 may be implemented in the imaging system100 as illustrated in FIG. 1. In some embodiments, one or moreoperations in the process 600 may be stored in the storage (e.g., theROM 230, the RAM 240) as a form of instructions, and invoked and/orexecuted by the computing device 140 (e.g., the processor 210 of thecomputing device 140). In some embodiments, the instructions may betransmitted in a form of electronic current or electrical signals.

In 602, the processor 210 (e.g., the data reception module 410) mayobtain preliminary projection values of a first object. In someembodiments, the first object may be a phantom. The imaging device(e.g., a multi-detector CT scanner) may scan the phantom and obtainpreliminary projection values (or projection data). In some embodiments,the radiation detectors of the multi-detector CT scanner may include aplurality of detector channels. The number of the detector channels maybe denoted as nChannelNum (nChannelNum=nChannelNumPerRow×nRowNum), wherenRowNum refers to the number of rows of the radiation detector, andnChannelNumPerRow refers to the number of detector channels per row. Toperform a calibration operation, the phantom may be placed at differentpositions within the scanning field of view of the CT scanner, andmultiple scans may be performed on the phantom. The number of scans maybe denoted as nScanNum, and the projection angle number for each scanmay be marked as nViewNum. For example, the multiple scans may beperformed by changing the distance between the center of the phantom andthe rotation center of the CT scanner. In some embodiments, the phantommay be a uniform phantom consisting of a single material. In someembodiments, the phantom may include a body made of a first material anda shell made of a second material. In some embodiments, the phantom maybe hollow. In some embodiments, the phantom may have a solid core. Insome embodiments, the phantom may be made of teflon, propylene,polyethylene, resin, or the like, or any combination thereof. In someembodiments, the phantom 910 may have some special local structures onthe surface and/or in the inside, including structures of differentsizes, such as a hole, a concave, a bulge, cross grain, or the like, orany combination thereof.

In 604, the processor 210 (e.g., the reconstruction module 440) maygenerate a preliminary image of the first object based on thepreliminary projection values of the first object. The preliminary imagemay be denoted as imgOrig_(k), where k refers to the k^(th) scan on thephantom. In some embodiments, the phantom may be scanned by X-ray beamsfrom an X-ray tube, and the X-ray beams that passed through the phantommay be received by the radiation detector(s). The radiation detector(s)may generate electrical signals based on the received X-ray beams. Theelectrical signals may be converted into digital signals via anAnalog-to-Digital Converter and the digital signals may be input to thecomputing device 140. To process the input digital signals, theprocessor 210 may divide each scanned layer of the phantom into aplurality of cuboids having the same volume. The processor 210 maydetermine an X-ray attenuation coefficient of each cuboid based on thedigital signals and arrange the X-ray attenuation coefficient of eachcuboid in a digital matrix. The processor 210 may further convert thedigital matrix into equal-area rectangles having various gray levels(i.e., pixels) via the Analog-to-Digital Converter. The rectangles maybe arranged according to the digital matrix to obtain a 2D CT image. Insome embodiments, the processor 210 may preprocess (or pre-correct) thepreliminary projection values. For example, the preprocessing mayinclude air correction, crosstalk correction, off-focal correction, beamhardening correction, or the like, or any combination thereof. In someembodiments, the data reception module 410 may send the preliminaryprojection values to the reconstruction module 440 for reconstructionoperations. Exemplary methods for reconstruction may include aniterative algorithm, a filtered back projection algorithm, a Radontransform algorithm, a direct Fourier algorithm, or the like, or anycombination thereof. Details regarding the determination of thepreliminary image may be found elsewhere in the present disclosure, forexample, FIG. 7.

In 606, the processor 210 (e.g., the calibration module 430) may processthe preliminary image to obtain a calibrated image. The calibrated imagemay be denoted as imgIdeal_(k). In some embodiments, for a uniformphantom composed of a single material, the processor may classify thepixels in the preliminary image into material pixels of the phantom bodyand air pixels according to a simple threshold method. As used herein,the material pixels of the phantom body may refer to pixelscorresponding to at least a part of the phantom, and the air pixels mayrefer to pixels corresponding to air. In some embodiments, a thresholdof pixel values may be predetermined for classifying the pixels in thepreliminary image. For example, the threshold may be 0, 1, 3, etc. Theprocessor 210 may determine whether the pixel value of each pixel in thepreliminary image is greater than the threshold. In response to adetermination that the pixel value of the pixel is equal to or less thanthe threshold, the processor 210 may determine that the pixel is an airpixel. In response to a determination that the pixel value of the pixelis greater than the threshold, the processor 210 may determine that thepixel is a material pixel of the phantom body. An average value of thepixel values of the material pixels of the phantom body may bedetermined and assigned as a new value to each of the material pixels ofthe phantom body in the calibrated image. The pixel values of the airpixel in the calibrated image may be set as zeros. In some embodiments,for a phantom including a body made of a first material and a shell madeof a second material, the processor 210 may classify the image pixelsinto the material pixels of the phantom body (also referred to as thefirst pixels), material pixels of the phantom shell (also referred to asthe second pixels), and the air pixels using an image segmentationalgorithm. Exemplary image segmentation algorithms may include a k-meansclustering algorithm, a maximum entropy algorithm, a maximum variancealgorithm, a Statistical Region Merging (SRM) algorithm, a V-net model,a convolutional neural network (CNN) model, or the like, or anycombination thereof. An average value of the pixel values of thematerial pixels of the phantom body may be determined and assigned as anew value to each of the material pixels of the phantom body in thecalibrated image. The pixel values of the material pixels of the phantomshell in the calibrated image may be kept consistent with the pixelvalue of the material pixels of the phantom shell in the preliminaryimage (imgOrig_(k)). The pixel values of the air pixel in the calibratedimage may be set as 0.

In 608, the processor 210 (e.g., the calibration module 430) maydetermine calibrated projection values based on the calibrated image. Insome embodiments, the processor 210 may perform an equal-spaced parallelbeam projection on the calibrated image to obtain the forward projectionvalues. In some embodiments, the processor 210 may perform anequiangular fan-beam projection on the calibrated image to obtain theforward projection values. In some embodiments, the processor 210 mayperform an interpolation on the forward projection values to obtain thecalibrated projection values corresponding to at least one actualposition of the at least one detector. The calibrated projection valuesmay be reversely rebined corresponding to the at least one actualposition of the at least one detector to obtain the calibratedprojection values. Details regarding the determination of the calibratedprojection values based on the calibrated image may also be foundelsewhere in the present disclosure, for example, in FIG. 8 and thedescriptions thereof.

In 610, the processor 210 (e.g., the calibration module 430) maydetermine at least one calibration coefficient based on the preliminaryprojection values and the calibrated projection values. In someembodiments, the at least one calibration coefficient may correspond tothe at least one detector. The at least one calibration coefficient maybe obtained using one or more mathematical methods. For example, theprocessor 210 may obtain the calibration coefficient using a polynomialfitting algorithm. As another example, the at least one calibrationcoefficient may be obtained using a cosine fitting algorithm, a Gaussianfitting algorithm, a least square fitting algorithm, or the like, or anycombination thereof. Details regarding the determination of the at leastone calibration coefficient may also be found elsewhere in the presentdisclosure, for example, in FIG. 10 and the descriptions thereof.

It should be noted that the above description regarding the process 600is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure. In some embodiments, one or more operations may be omittedand/or one or more additional operations may be added. For example, theprocess 600 may further include an operation to obtain an imagesegmentation model from the storage device a storage (e.g., the ROM 230,the RAM 240) to classify the pixels in the preliminary image.

FIG. 7 is a flowchart illustrating an exemplary process for obtaining apreliminary image according to some embodiments of the presentdisclosure. At least a portion of process 700 may be implemented on thecomputing device 140 as illustrated in FIG. 2 or the mobile device 300as illustrated in FIG. 3. In some embodiments, one or more operations ofthe process 700 may be implemented in the imaging system 100 asillustrated in FIG. 1. In some embodiments, one or more operations inthe process 700 may be stored in the storage (e.g., the ROM 230, the RAM240) as a form of instructions, and invoked and/or executed by thecomputing device 140 (e.g., the processor 210 of the computing device140). In some embodiments, the instructions may be transmitted in a formof electronic current or electrical signals.

In 702, the processor 210 (e.g., the data reception module 410) mayobtain preliminary projection values. In some embodiments, the processor210 may obtain the preliminary projection values from one or morecomponents of the imaging system 100 shown in FIG. 1 (e.g., theradiation detector 170, the ROM 230 and/or the RAM 240 of the computingdevice 140). In some embodiments, the processor 210 may obtain thepreliminary projection values from an external device.

In 704, the processor 210 (e.g., the preprocessing module 420) maypreprocess the preliminary projection values to obtain preprocessedprojection values. For example, the preprocessing operation may includeair correction, crosstalk correction, off-focal correction, beamhardening correction, or the like, or any combination thereof.

In 706, the processor 210 (e.g., the reconstruction module 440) mayperform a reconstruction based on the preprocessed projection values toobtain a preliminary image with one or more artifacts. The one or moreartifacts may include a streak artifact, a shading artifact, a ringartifact, a banding artifact, or the like, or any combination thereof.An exemplary cause of the streak artifact may include improper datasampling, volume effects, patient motion, or the like, or anycombination thereof. An exemplary cause of a shading artifact mayinclude volume effects, beam hardening, off-focal radiation,incompleteness of the preliminary projection values, or the like, or anycombination thereof. An exemplary cause of a ring artifact may includemalfunction of the detector channels, the inconsistence of the detectorchannels, or the like. For instance, the inconsistency of the detectorchannels may include inconsistent intensity responses of the radiationdetector units and the inconsistent responses to photons of differentenergy levels. In some embodiments, the processor 210 may reconstructthe preliminary image using an imaging reconstruction algorithm. Anexemplary imaging reconstruction algorithm may include an iterativealgorithm, a filtered back projection algorithm, a Radon transformalgorithm, a direct Fourier algorithm, or the like, or any combinationthereof.

It should be noted that the above description regarding the process 700is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure.

FIG. 8 is a flowchart illustrating an exemplary process for obtainingcalibrated projection values according to some embodiments of thepresent disclosure. At least a portion of process 800 may be implementedon the computing device 140 as illustrated in FIG. 2 or the mobiledevice 300 as illustrated in FIG. 3. In some embodiments, one or moreoperations of the process 800 may be implemented in the imaging system100 as illustrated in FIG. 1. In some embodiments, one or moreoperations in the process 800 may be stored in the storage (e.g., theROM 230, the RAM 240) as a form of instructions, and invoked and/orexecuted by the computing device 140 (e.g., the processor 210 of thecomputing device 140). In some embodiments, the instructions may betransmitted in a form of electronic current or electrical signals.

In 802, the processor 210 (e.g., the calibration module 430) may performan equal-spaced parallel beam projection on the calibrated image toobtain the forward projection values. In some embodiments, the radiationdetector(s) 170 may be equal-spaced. In some embodiments, the radiationdetector(s) 170 may be located in a plane or a curved surface. Theforward projection values obtained by the equal-spaced parallel beamprojection may be denoted as projFP_(m,n,k) (m=1, 2, . . . ,nChannelNumFPPerRow, n=1, 2, . . . , nViewNumFP), wherenChannelNumFPPerRow denotes the number of detector channels per row forthe equal-spaced parallel beam projection, nViewNumFP denotes theprojection angle number for each scan, and k represents the k^(th) scanon the phantom. In some embodiments, other types of forward projectionsmay be performed on the calibrated image to obtain the forwardprojection values, such as a forward projection of fan beams. Forexample, the forward projection of fan beams may include an equiangularfan-beam projection, an equal-spaced fan-beam projection, etc. In someembodiments, the processor 210 may perform the forward projection of fanbeams according to the geometric structure of the imaging device (e.g.,a CT scanner). The forward projection values obtained by the forwardprojection of fan beams may be denoted as projMeas_(i,j,k) (i=1, 2, . .. , nChannelNum, j=1, 2, . . . , nViewNum), where k represents thek^(th) scan on the phantom.

In 804, the processor 210 (e.g., the calibration module 430) may performan interpolation on the forward projection values to obtain thecalibrated projection values corresponding to at least one actualposition of the at least one detector. As used herein, the term“interpolation” refers to a process of estimating a target valuecorresponding to an intermediate value of independent variable(s) basedon the independent variable(s) and known values corresponding to theindependent variable(s). In some embodiments, the calibrated projectionvalues obtained by the equal-spaced parallel beam projection may bedenoted as projParallel_(i,n,k). In some embodiments,projParallel_(i,n,k) (i.e., the target value) may be determinedaccording to an interpolation function based on a distance between aradiation beam and an rotation center of the imaging device (i.e., theindependent variable of the interpolation function), a forwardprojection value obtained through a forward projection on the calibratedimage (i.e., a known value corresponding to the independent variable ofthe interpolation function), and a distance between a radiation detectorand the rotation center of the imaging device (i.e., an intermediatevalue of the independent variable). In some embodiments, theinterpolation function may be related to an interpolation algorithm.Exemplary interpolation algorithms may include a nearest-neighborinterpolation algorithm, a spline interpolation algorithm, a cubicinterpolation algorithm, a piecewise linear interpolation algorithm, orthe like, or any combination thereof. In some embodiments,projParallel_(i,n,k) may be obtained using the following equation (1):projParallel_(i,n,k)=interp1(fDetPosFP_(m),projFP_(m,n,k),fDetPosOrg_(i)),  (1)where i=1, 2, . . . , nChannelNum; m=1, 2, . . . , nChannelNumFPPerRow;n=1, 2, . . . , nViewNumFP; fDetPosFP_(m) denotes the distance betweenthe m^(th) radiation beam (e.g., X-ray) of the equal-spaced parallelbeams and the rotation center; fDetPosOrg_(i) denotes the distancebetween the radiation detector i and the rotation center; and interp1denotes an interpolation function for determining theprojParallel_(i,n,k).

In 806, the processor 210 (e.g., the calibration module 430) mayreversely rebin the calibrated projection values corresponding to the atleast one actual position of the at least one detector to obtain thecalibrated projection values. In some embodiments, after obtaining thecalibrated projection values of parallel beams projParallel_(i,n,k)corresponding to the at least one actual position of the radiationdetector(s) 170, the processor 210 may transform the calibratedprojection values of parallel beams to obtain the calibrated projectionvalues of other types of beams. For example, the processor 210 mayreversely rebin the calibrated projection values of parallel beamsprojParallel_(i,n,k) to obtain the calibrated projection values of thefan beams. In some embodiments, the processor 210 may reversely rebinthe calibrated projection values for each radiation detector, forexample, according to the following equation (2):projIdeal_(i,j,k)interp1(viewAngleFP_(n),projParallel_(i,n,k),θ_(i))  (2)where viewAngleFP_(n) denotes the n^(th) projection angle of anequal-spaced parallel beam, and θ_(i) denotes a constant group. In someembodiments, the constant group may include one or more anglescorresponding to the at least one radiation detector. In someembodiments, θ_(i) may be determined based on a projection angle forscanning the phantom, an offset angle after each scan of the focus ofthe bulb tube, and the angle of the detector i relative to the focus ofthe bulb tube. In some embodiments, the constant group θ_(i) may bedetermined according to the following equation (3):θ_(i)=mod(viewAngle_(j)+β_(FS)−γ_(i),2π),  (3)Wherein ViewAngle_(j) denotes the j^(th) projection angle for scanningthe phantom, β_(FS) is the offset angle after each scan of the focus ofthe bulb tube, γ_(i) is the angle of the detector i relative to thefocus of the bulb tube, and the return value of mod(x, y) is x−n*y (n isan integer no greater than x/y).

It should be noted that the above description regarding the process 800is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure. In some embodiments, one or more operations may be omittedand/or one or more additional operations may be added. For example, theoperation 806 may be omitted if the calibrated projection valuesobtained based on the equal-spaced parallel beam projection do not needto be transformed to calibrated projection values of other types ofbeams (e.g., fan beams).

FIGS. 9A-9B are schematic diagrams illustrating exemplary phantomsaccording to some embodiments of the present disclosure. As shown inFIG. 9A, the single material for the phantom 910 may include teflon,propylene, polyethylene, resin, or the like, or any combination thereof.The shape of the phantom 910 may include but not limited to a cylinder,a sphere, a cube, a simulation shape of a human body or a part thereof(e.g., a whole body, a head, a lung, an abdomen), or the like. In someembodiments, the phantom 910 may have a solid core. In some embodiments,the phantom 910 may be hollow. In some embodiments, the phantom 910 maycontain a medium, such as water or water-equivalent plastic. In someembodiments, the phantom 910 may include air in the inside. In someembodiments, the phantom 910 may have some special local structures onthe surface and/or in the inside, including structures of differentsizes, such as a hole, cross grain, a letter, a circle, or the like, orany combination thereof. As shown in FIG. 9B, the phantom may include ashell 920 and a non-shell structure 930. The non-shell structure 930 mayalso be referred to as the phantom body. In some embodiments, the shell920 and/or the non-shell structure 930 may be made of differentmaterials. For example, the shell 920 may be made of a second material,and the non-shell structure 930 may be made of a first material. In someembodiments, the first material and/or the second material may besimilar to the single material of the phantom 910. In some embodiments,the shell 920 may have a uniform thickness, such as 0.5 cm, 1 cm, 2 cm,or the like. In some embodiments, the shell 920 may have a non-uniformthickness. The constituent materials of the shell 920 and/or thenon-shell structure 930 may include teflon, propylene, polyethylene,resin, or the like, or any combination thereof. In some embodiments, theshell 920 may include air. In some embodiments, the shell 920 and thenon-shell structure 930 may be made of different materials. For example,the shell 920 may be made of polyethylene and the non-shell structure930 may be made of water equivalent plastic.

It should be noted that the above description regarding the process 600is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure. For example, the phantom may have multiple layers of shellmade of the same or different materials.

FIG. 10 is a schematic diagram illustrating an exemplary fitting resultof the calibrated projection values and the preprocessed projectionvalues according to some embodiments of the present disclosure. As shownin FIG. 10, each preprocessed projection value and the correspondingcalibrated projection value may be represented by a point (e.g., afitting point 1010) in a two-dimensional coordinate system. The X-axisand the Y-axis of the two-dimensional coordinate system may correspondto the preprocessed projection values and the calibrated projectionvalues, respectively. The processor 210 may further perform thepolynomial fitting (e.g., a polynomial curve fitting) on two or morefitting points to obtain a polynomial containing the calibrationcoefficient. An exemplary fitting curve 1020 corresponding to thepolynomial is shown in the two-dimensional coordinate system in FIG. 10.In some embodiments, the preprocessed projection value and thecalibrated projection values may be fitted according to the followingequation (4):projIdeal_(i,j,k)=Σ_(p=0) ^(p)α_(i,p)*proMeas_(i,j,k) ^(p),  (4)where j=1, 2, . . . , nViewNum; k=1, 2, . . . , nScanNum; α_(i,p) (p=0,. . . , P) is the calibration coefficient of the radiation detectorchannel; and P is the polynomial order of the fitting algorithms.Similar calculations may be performed on all the detector channels toobtain all the calibration coefficients corresponding to all theradiation detectors. The calibration coefficient α_(i,p) may be used toremove artifacts in other preliminary images containing artifacts (e.g.,obtained by one or more scans on a second object). For example, thesecond object may be a patient.

It should be noted that the above description regarding the process 600is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure. For example, other fitting algorithms may also be used togenerate the fitting result of the calibrated projection values and thepreprocessed projection values, such as a cosine fitting algorithm, aGaussian fitting algorithm or a least square fitting algorithm.

FIG. 11 is a flowchart illustrating an exemplary process forreconstructing a corrected image according to some embodiments of thepresent disclosure. At least a portion of process 1100 may beimplemented on the computing device 140 as illustrated in FIG. 2 or themobile device 300 as illustrated in FIG. 3. In some embodiments, one ormore operations of the process 1100 may be implemented in the imagingsystem 100 as illustrated in FIG. 1. In some embodiments, one or moreoperations in the process 1100 may be stored in the storage (e.g., theROM 230, the RAM 240) as a form of instructions, and invoked and/orexecuted by the computing device 140 (e.g., the processor 210 of thecomputing device 140). In some embodiments, the instructions may betransmitted in a form of electronic current or electrical signals.

In 1102, the processor 210 (e.g., the data reception module 410) mayobtain preliminary projection values of a second object. The secondobject may include a body, a substance, an object, or the like, or acombination thereof. In some embodiments, the object may include aspecific portion of a body, such as a head, a thorax, an abdomen, or thelike, or a combination thereof. In some embodiments, the object mayinclude a specific organ or region of interest, such as an esophagus, atrachea, a bronchus, a stomach, a gallbladder, a small intestine, acolon, a bladder, a ureter, a uterus, a fallopian tube, etc. In someembodiments, the preliminary projection values of the second object maybe obtained by the same imaging device for scanning the first object.

In 1104, the processor 210 (e.g., the preprocessing module 420) maypreprocess the preliminary projection values to obtain preprocessedprojection values. In some embodiments, the preprocessing may eliminateor reduce the influence of known physical factors on the preliminaryprojection values. For example, the preprocessing may include aircorrection, crosstalk correction, off-focal correction, beam hardeningcorrection, or the like, or any combination thereof. The preprocessedprojection values may be denoted as ProjOrig.

In 1106, the processor 210 (e.g., the data reception module 410) mayobtain at least one corresponding calibration coefficient from acalibration table generated based on the at least one calibrationcoefficient. In some embodiments, the processor 210 may obtain the atleast one calibration coefficient α_(i,p) corresponding to the detectorchannel i from a storage (e.g., the ROM 230, the RAM 240 of thecomputing device 140).

In 1108, the processor 210 (e.g., the calibration module 430) maydetermine corrected projection values based on the at least onecorresponding calibration coefficient. In some embodiments, thecorrected projection values ProjCorr_(i) may be determined according tothe following equation (5):ProjCorr_(i)=Σ_(p=0) ^(p)α_(i,p)*ProjOrig_(i) ^(p),  (5)

In 1110, the processor 210 (e.g., the reconstruction module 440) mayreconstruct a corrected image of the second object based on thecorrected projection values. The corrected image may include noartifacts or reduced artifacts. The processor 210 may reconstruct thecorrected image of the second object using a common reconstructionalgorithm. An exemplary reconstruction algorithm may include aniterative algorithm, a filtered back projection algorithm (FBP), a Radontransform algorithm, a direct Fourier algorithm, an ordered subsetexpectation (OSEM) maximization algorithm, or the like, or anycombination thereof.

It should be noted that the above description regarding the process 500is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure.

FIG. 12 is a flowchart illustrating an exemplary process for determiningat least one calibration coefficient and generating a calibration tableaccording to some embodiments of the present disclosure. At least aportion of process 1200 may be implemented on the computing device 140as illustrated in FIG. 2 or the mobile device 300 as illustrated in FIG.3. In some embodiments, one or more operations of the process 1200 maybe implemented in the imaging system 100 as illustrated in FIG. 1. Insome embodiments, one or more operations in the process 1200 may bestored in the storage (e.g., the ROM 230, the RAM 240) as a form ofinstructions, and invoked and/or executed by the computing device 140(e.g., the processor 210 of the computing device 140). In someembodiments, the instructions may be transmitted in a form of electroniccurrent or electrical signals.

In 1202, the processor 210 (e.g., the data reception module 410) mayobtain preliminary projection values of a phantom. In some embodiments,the phantom may have a structure similar to that of a human body. As anexample, an elliptical cylinder phantom having an elliptical crosssection may be used in the process 1200, since many parts of the humanbody may have an elliptical cross section. When the cross section of thephantom is an ellipse, each radiation detector may receive the energyintensity of X-rays that have passed regions of various thicknesses ofthe phantom during the rotation of the gantry. Moreover, the weight ofthe phantom may be reduced by increasing the ratio of the long-axis toshort-axis of the ellipse. In some embodiments, the phantom may be auniform phantom composed of a single material. For example, the materialmay include polypropylene, polyethylene, polytetrafluoroethylene, or thelike, or any combination thereof. In some embodiments, the phantom maybe a relatively large cylinder sleeve (also referred to as a shell)containing a relatively small cylinder in the inside. The relativelysmall cylinder and the relatively large cylinder sleeve may be made of asame material or a different material. In some embodiments, the methodfor scanning the phantom may include placing the phantom in differentpositions within the scanning range of the imaging device to simulatedifferent positions of different parts of the human body within thescanning range of the imaging device. For example, the phantom may beplaced near the center of the scanning range of the imaging device. Thedistance between the center of the scanning range and the phantom (e.g.,the geometrical center of the cross section of the phantom) may be 50mm, 100 mm, or the like. The processor 210 may obtain the tomographicdata (i.e., preliminary projection values) of at least one scan on thephantom at different positions. The tomographic data may be used forlater image correction. For example, the processor 210 may determine theat least one calibration coefficient based on the tomographic data of atleast one scan on the phantom at different positions. The preliminaryprojection data of a second object (e.g., a patient) may be correctedaccording to the at least one calibration coefficient.

FIG. 13 is a schematic diagram illustrating an exemplary scan on anobject according to some embodiments of the present disclosure. 1310represents an X-ray tube, 1320 represents a radiation detector, and 1330represents the phantom. As shown in FIG. 13, the phantom 1330 is placedat the center of the scanning range of the imaging device (i.e., thecenter of the ellipse is near the rotation center of the gantry). TheX-ray tube 1310 may emit X-rays toward the X-ray radiation detector1320, which may pass through the phantom 1330. The X-rays passingthrough the phantom 1330 may be detected by the radiation detector 1320to obtain the preliminary projection values when the phantom 1330 isplaced at the center. The position for the phantom may cause the fullexposure of the phantom 1330 to X-rays propagating from the X-ray tube1310 to the X-ray radiation detector 1320 in a fan-shaped region 1340.The radiation detector 1320 may include a plurality of detectorchannels. During the scanning process, the X-ray tube 1310 and theradiation detector 1320 may be rotated around the rotation center of thegantry of the imaging device. After one or more rounds of rotation ofthe X-ray tube 1310 and the X-ray radiation detector 1320, thepreliminary projection values of the phantom at the rotation center. Thephantom may be placed in different positions within the scanning rangeof the imaging device to obtain preliminary projection values of thephantom at different positions. For example, the distance between thecenter of the scanning range and the phantom (e.g., the geometricalcenter of the cross section of the phantom) may be 50 mm, 100 mm, or thelike.

As shown in FIG. 12, in 1204, the processor 210 (e.g., the preprocessingmodule 420) may preprocess the preliminary projection values of thephantom to obtain preprocessed projection values. In some embodiments,the preprocessing operation may eliminate or reduce the influence ofknown physical factors on the preliminary projection values. Forexample, the preprocessing may include air correction, crosstalkcorrection, off-focal correction, beam hardening correction, or thelike, or any combination thereof. In some embodiments, the preprocessedprojection values may be denoted as ProjM_(i,j,k), where 1=1, 2, . . . ,nChannelNum; j=1, 2, . . . , nViewNum; and k=1, 2, . . . , nScanNum;nChannelNum denotes the number of radiation detector units; nViewNumdenotes the projection angle number for each tomographic scan; andnScanNum denotes the number of scans.

In 1206, the processor 210 (e.g., the calibration module 430) may obtaincalibrated projection values of the phantom. To obtain the calibratedprojection values of the phantom, the processor 210 (e.g., theconstruction module 440) may perform a reconstruction on thepreprocessed projection values ProjM_(i,j,k) of each scan to obtain apreliminary image denoted as Image_(k). The preliminary image may haveone or more artifacts, such as a streak artifact, a shading artifact, aring artifact, a banding artifact, or the like, or any combinationthereof. The processor 210 (e.g., the calibration module 430) mayextract the interface between the phantom and the air in the preliminaryimage Image_(k). An elliptical equation may be used to fit the pixels ofthe interface to obtain the cross-section equation of the cross sectionof the phantom. In some embodiment, the cross-section equation may bethe following equation (6)

$\begin{matrix}{{{\frac{\left\lbrack {{\left( {x - x_{0}} \right)*{\cos(t)}} + {\left( {y - y_{0}} \right)*{\sin(t)}}} \right\rbrack^{2}}{a^{2}} + \frac{\left\lbrack {{\left( {x - x_{0}} \right)*{\sin(t)}} + {\left( {y - y_{0}} \right)*{\cos(t)}}} \right\rbrack^{2}}{b^{2}}} = 1},} & (6)\end{matrix}$Where (x₀, y₀) denotes the center position of the phantom, t denotes anangle between the long axis of the phantom section and the coordinatesystem including the X and Y axes (e.g., the coordinate system shown inFIG. 1). For the X-rays emitted from the X-ray tube after beingattenuated by the phantom and reached the radiation detector, only onestraight line equation (also referred to as a scanning equation) foreach X-ray may be determined since the X-ray may pass the focuscoordinate of the X-ray tube (X_(S), Y_(S)), and the coordinates of theradiation detector (X_(dI), Y_(dI)). In some embodiments, the straightline equation of the X-ray may be the following equation (7):Ax+By+C=0,  (7)Where A, B, and C are parameters including X-ray rotation information,A=Y_(dI)−Y_(S); B=X_(S)−X_(dI); and C=X_(dI)*Y_(S)−X_(S)*Y_(dI). Theprocessor 210 may determine whether there is a solution that satisfiesboth the equation (6) and the equation (7). There may be three cases forthe solution. In response to a determination that there is no solutionsatisfying both the equation (6) and the equation (7), it may indicatethat there is no intersection point between the straight line (X-ray)and the ellipse, and the corresponding calibrated projection values maybe determined as 0. In response to a determination that there is onlyone solution satisfying both the equation (6) and the equation (7), itmay indicate that the straight line (X-ray) and the ellipse are tangent,and the corresponding calibrated projection values may also bedetermined as 0. In response to a determination that there are twosolutions satisfying both the equation (6) and the equation (7), denotedas (X₁, Y₁) and (X₂, Y₂), respectively, it may indicate that thestraight line (X-ray) intersects the ellipse. The calibrated projectionvalues may be determined based on the distance between two intersectionpoints. In some embodiments, the calibrated projection values may bedetermined according to the following equation (8):ProjI _(I,j,k)=√{square root over ((X ₁ −X ₂)²+(Y ₁ −Y ₂)²)}*μ₀,  (8)where μ₀ denotes the linear attenuation coefficient of the phantom(e.g., a rectangle mentioned in operation 604) regarding the X-ray withthe energy E₀kev, E₀ is the energy of the X-ray, key (kiloelectronvolts) is the unit of energy, and ProjI_(I,j,k) is the calibratedprojection values. In this manner, the calibrated projection values ofthe radiation detector i may be obtained by establishing a scanningequation of a straight line passing through the coordinate of the focusof the X-ray tube and the radiation detector i, and determine thesolution(s) satisfying both the scanning equation and the cross-sectionequation.

In 1208, the processor 210 (e.g., the calibration module 430) maydetermine at least one calibration coefficient based on the preprocessedprojection values and the calibrated projection values. In someembodiments, the calibration coefficient corresponding to each radiationdetector may be determined according to one or more processed projectionvalues related to each radiation detector and the corresponding one ormore calibrated projection values. Specifically, for each radiationdetector i, all of the one or more preprocessed projection valuesProjM_(I,j,k) of the radiation detector i may be used as an independentvariable, and the one or more corresponding calibrated projection valuesProjM_(I,j,k) may be used as a dependent variable. The processor 210 mayperform an N-order polynomial fitting on the preprocessed projectionvalue(s) and the calibrated projection value(s) to obtain thecalibration coefficient α_(I,n), for example, as shown in the followingequation (9):ProjI _(I,j,k)=Σ_(n=0) ^(N)α_(I,n)*ProjM _(I,j,k) ^(n)  (9)where j=1, 2, . . . , nViewNum; k=1, 2, . . . , nScanNum; nViewNumrefers to the projection angle for each scan; and nScanNum is the numberof scans.

In 1210, the processor 210 (e.g., the calibration coefficient 420) maygenerate a calibration table based on the at least one calibrationcoefficient. For example, the calibration table may include the locationand/or an identification number of each of the at least one radiationdetector and the at least one calibration coefficient corresponding tothe at least one radiation detector. In some embodiments, thecalibration table may be stored in a storage (e.g., the ROM 230, the RAM240 of the computing device 140). In some embodiments, the calibrationtable may be stored in an external data source, such as a mobile harddisk drive.

It should be noted that the above description regarding the process 500is merely provided for the purposes of illustration, and not intended tolimit the scope of the present disclosure. For persons having ordinaryskills in the art, multiple variations or modifications may be madeunder the teachings of the present disclosure. However, those variationsand modifications do not depart from the scope of the presentdisclosure.

Having thus described the basic concepts, it may be rather apparent tothose skilled in the art after reading this detailed disclosure that theforegoing detailed disclosure is intended to be presented by way ofexample only and is not limiting. Various alterations, improvements, andmodifications may occur and are intended to those skilled in the art,though not expressly stated herein. These alterations, improvements, andmodifications are intended to be suggested by this disclosure and arewithin the spirit and scope of the exemplary embodiments of thisdisclosure.

Moreover, certain terminology has been used to describe embodiments ofthe present disclosure. For example, the terms “one embodiment,” “anembodiment,” and “some embodiments” mean that a particular feature,structure or characteristic described in connection with the embodimentis included in at least one embodiment of the present disclosure.Therefore, it is emphasized and should be appreciated that two or morereferences to “an embodiment” or “one embodiment” or “an alternativeembodiment” in various portions of this specification are notnecessarily all referring to the same embodiment. Furthermore, theparticular features, structures or characteristics may be combined assuitable in one or more embodiments of the present disclosure.

Further, it will be appreciated by one skilled in the art, aspects ofthe present disclosure may be illustrated and described herein in any ofa number of patentable classes or context including any new and usefulprocess, machine, manufacture, or composition of matter, or any new anduseful improvement thereof. Accordingly, aspects of the presentdisclosure may be implemented entirely hardware, entirely software(including firmware, resident software, micro-code, etc.) or combiningsoftware and hardware implementation that may all generally be referredto herein as a “module,” “unit,” “component,” “device,” or “system.”Furthermore, aspects of the present disclosure may take the form of acomputer program product embodied in one or more computer readable mediahaving computer readable program code embodied thereon.

A computer readable signal medium may include a propagated data signalwith computer readable program code embodied therein, for example, inbaseband or as part of a carrier wave. Such a propagated signal may takeany of a variety of forms, including electro-magnetic, optical, or thelike, or any suitable combination thereof. A computer readable signalmedium may be any computer readable medium that is not a computerreadable storage medium and that may communicate, propagate, ortransport a program for use by or in connection with an instructionexecution system, apparatus, or device. Program code embodied on acomputer readable signal medium may be transmitted using any appropriatemedium, including wireless, wireline, optical fiber cable, RF, or thelike, or any suitable combination of the foregoing.

Computer program code for carrying out operations for aspects of thepresent disclosure may be written in any combination of one or moreprogramming languages, including an object oriented programming languagesuch as Java, Scala, Smalltalk, Eiffel, JADE, Emerald, C++, C#, VB. NET,Python or the like, conventional procedural programming languages, suchas the “C” programming language, Visual Basic, Fortran 2003, Perl, COBOL2002, PHP, ABAP, dynamic programming languages such as Python, Ruby, andGroovy, or other programming languages. The program code may executeentirely on the user's computer, partly on the user's computer, as astand-alone software package, partly on the user's computer and partlyon a remote computer or entirely on the remote computer or server. Inthe latter scenario, the remote computer may be connected to the user'scomputer through any type of network, including a local area network(LAN) or a wide area network (WAN), or the connection may be made to anexternal computer (for example, through the Internet using an InternetService Provider) or in a cloud computing environment or offered as aservice such as a Software as a Service (SaaS).

Furthermore, the recited order of processing elements or sequences, orthe use of numbers, letters, or other designations, therefore, is notintended to limit the claimed processes and methods to any order exceptas may be specified in the claims. Although the above disclosurediscusses through various examples what is currently considered to be avariety of useful embodiments of the disclosure, it is to be understoodthat such detail is solely for that purpose and that the appended claimsare not limited to the disclosed embodiments, but, on the contrary, areintended to cover modifications and equivalent arrangements that arewithin the spirit and scope of the disclosed embodiments. For example,although the implementation of various components described above may beembodied in a hardware device, it may also be implemented as a softwareonly solution, e.g., an installation on an existing server or mobiledevice.

Similarly, it should be appreciated that in the foregoing description ofembodiments of the present disclosure, various features are sometimesgrouped together in a single embodiment, figure, or description thereoffor the purpose of streamlining the disclosure aiding in theunderstanding of one or more of the various embodiments. This method ofdisclosure, however, is not to be interpreted as reflecting an intentionthat the claimed object matter requires more features than are expresslyrecited in each claim. Rather, claim object matter lie in less than allfeatures of a single foregoing disclosed embodiment.

I claim:
 1. A method implemented on a computing device having at leastone storage device storing a set of instructions for determining atleast one artifact calibration coefficient, and at least one processorin communication with the at least one storage device, comprising:obtaining, by the at least one processor, preliminary projection valuesof a first object generated based on radiation rays that are emittedfrom a radiation emitter and passed through the first object, theradiation rays being detected by at least one radiation detector;generating, by the at least one processor, a preliminary image of thefirst object based on the preliminary projection values of the firstobject; generating, by the at least one processor, calibrated projectionvalues of the first object based on the preliminary image; determining,by the at least one processor, a relationship between the preliminaryprojection values and the calibrated projection values; for each of theat least one radiation detector, determining, by the at least oneprocessor, a location of the radiation detector; and determining, by theat least one processor, an artifact calibration coefficientcorresponding to the radiation detector based on the relationshipbetween the preliminary projection values and the calibrated projectionvalues and the location of the radiation detector; wherein thegenerating the calibrated projection values of the first object based onthe preliminary image includes: obtaining a cross-section equation ofthe first object based on the preliminary image of the first object;obtaining a series of scanning equations, wherein each of the series ofscanning equations is associated with one of the radiation rays; anddetermining the calibrated projection values of the first object basedon the cross-section equation and the series of scanning equations ofthe first object.
 2. The method of claim 1, wherein the generating thecalibrated projection values of the first object based on thepreliminary image comprises: generating a calibrated image of the firstobject based on the preliminary image; and generating the calibratedprojection values based on the calibrated image.
 3. The method of claim2, wherein the first object is a phantom made of a single material, andthe generating the calibrated image of the first object based on thepreliminary image comprises: obtaining a value of each of pixels in thepreliminary image; determining an average value of at least portion ofthe pixels in the preliminary image; and assigning the average value ofthe at least portion of the pixels as a new value to the each of the atleast portion of the pixels in the preliminary image to generate thecalibrated image.
 4. The method of claim 2, wherein the first object isa phantom including a body made of a first material and a shell made ofa second material, and the generating the calibrated image of the firstobject based on the preliminary image comprises: obtaining a value ofeach of first pixels in the preliminary image associated with the bodyof the first object and a value of each of second pixels in thepreliminary image associated with the shell of the first object;determining an average value of the first pixels; and assigning theaverage value of the first pixels as a new value to the each of thefirst pixels and retaining the value of the each of second pixels togenerate the calibrated image.
 5. The method of claim 2, wherein thegenerating the calibrated projection values based on the calibratedimage comprises: performing a forward projection on the calibrated imageto generate forward projection values; and for each of the at least oneradiation detector, determining a calibrated projection value for theradiation detector based on the location of the radiation detector andthe forward projection values.
 6. The method of claim 1, wherein thedetermining the calibrated projection values of the first object basedon the cross-section equation and the series of scanning equations ofthe first object comprises: for each of the series of scanningequations, determining, when there is no solution satisfying both thescanning equation and the cross-section equation, the calibratedprojection value as zero; determining, when there is only one solutionsatisfying both the scanning equation and the cross-section equation,the calibrated projection value as zero; and determining, when there aretwo solutions satisfying both the scanning equation and thecross-section equation, the calibrated projection value based on thedistance between the two solutions.
 7. The method of claim 1, furthercomprising: performing a preprocessing on the preliminary projectionvalues to generate preprocessed projection values; and generating thepreliminary image based on preprocessed projection values.
 8. The methodof claim 1, further comprising: obtaining, by the at least oneprocessor, preliminary projection values of a second object generatedbased on radiation rays that are emitted from the radiation emitter andpassed through the second object, the radiation rays being detected bythe at least one radiation detector; determining corrected projectionvalues of the second object based on the preliminary projection valuesof the second object and the at least one artifact calibrationcoefficient associated with the at least one radiation detector; andgenerating a corrected image of the second object based on the correctedprojection values.
 9. The method of claim 1, wherein the relationshipbetween the preliminary projection values and the calibrated projectionvalues is represented by a fitting curve.
 10. A system for determiningat least one artifact calibration coefficient, comprising: at least onestorage medium storing a set of instructions; and at least one processorconfigured to communicate with the at least one storage medium, whereinwhen executing the set of instructions, the at least one processor isdirected to cause the system to: obtain preliminary projection values ofa first object generated based on radiation rays that are emitted from aradiation emitter and passed through the first object, the radiationrays being detected by at least one radiation detector; generate apreliminary image of the first object based on the preliminaryprojection values of the first object; generate calibrated projectionvalues of the first object based on the preliminary image; determine arelationship between the preliminary projection values and thecalibrated projection values; for each of the at least one radiationdetector, determine a location of the radiation detector; and determinean artifact calibration coefficient corresponding to the radiationdetector based on the relationship between the preliminary projectionvalues and the calibrated projection values and the location of theradiation detector; wherein to generate the calibrated projection valuesof the first object based on the preliminary image, the at least oneprocessor is directed to cause the system to: obtain a cross-sectionequation of the first object based on the preliminary image of the firstobject; obtain a series of scanning equations, wherein each of theseries of scanning equations is associated with one of the radiationrays; and determine the calibrated projection values of the first objectbased on the cross-section equation and the series of scanning equationsof the first object.
 11. The system of claim 10, wherein to generate thecalibrated projection values of the first object based on thepreliminary image, the at least one processor is directed to cause thesystem to: generate a calibrated image of the first object based on thepreliminary image; and generate the calibrated projection values basedon the calibrated image.
 12. The system of claim 11, wherein the firstobject is a phantom made of a single material, and to generate thecalibrated image of the first object based on the preliminary image, theat least one processor is directed to cause the system to: obtain avalue of each of pixels in the preliminary image; determine an averagevalue of at least portion of the pixels in the preliminary image; andassign the average value of the at least portion of the pixels as a newvalue to the each of the at least portion of the pixels in thepreliminary image to generate the calibrated image.
 13. The system ofclaim 11, wherein the first object is a phantom including a body made ofa first material and a shell made of a second material, and to generatethe calibrated image of the first object based on the preliminary image,the at least one processor is directed to cause the system to: obtain avalue of each of first pixels in the preliminary image associated withthe body of the first object and a value of each of second pixels in thepreliminary image associated with the shell of the first object;determine an average value of the first pixels; and assign the averagevalue of the first pixels as a new value to the each of the first pixelsand retaining the value of the each of second pixels to generate thecalibrated image.
 14. The system of claim 11, wherein to generating thecalibrated projection values based on the calibrated image, the at leastone processor is directed to cause the system to: perform a forwardprojection on the calibrated image to generate forward projectionvalues; and for each of the at least one radiation detector, determine acalibrated projection value for the radiation detector based on thelocation of the radiation detector and the forward projection values.15. The system of claim 10, wherein to determine the calibratedprojection values of the first object based on the cross-sectionequation and the series of scanning equations of the first object, theat least one processor is directed to cause the system to: for each ofthe series of scanning equations, determine, when there is no solutionsatisfying both the scanning equation and the cross-section equation,the calibrated projection value as zero; determine, when there is onlyone solution satisfying both the scanning equation and the cross-sectionequation, the calibrated projection value as zero; and determine, whenthere are two solutions satisfying both the scanning equation and thecross-section equation, the calibrated projection value based on thedistance between the two solutions.
 16. The system of claim 10, whereinthe relationship between the preliminary projection values and thecalibrated projection values is represented by a fitting curve.
 17. Thesystem of claim 10, wherein the at least one processor is directed tocause the system to: perform a preprocessing on the preliminaryprojection values to generate preprocessed projection values; andgenerate the preliminary image based on preprocessed projection values.18. The system of claim 10, wherein the at least one processor isdirected to cause the system to: obtain preliminary projection values ofa second object generated based on radiation rays that are emitted fromthe radiation emitter and passed through the second object, theradiation rays being detected by the at least one radiation detector;determine corrected projection values of the second object based on thepreliminary projection values of the second object and the at least oneartifact calibration coefficient associated with the at least oneradiation detector; and generate a corrected image of the second objectbased on the corrected projection values.
 19. A non-transitory computerreadable medium, comprising at least one set of instructions fordetermining at least one artifact calibration coefficient, wherein whenexecuted by at least one processor of a computer device, the at leastone set of instructions directs the at least one processor to: obtainpreliminary projection values of a first object generated based onradiation rays that are emitted from a radiation emitter and passedthrough the first object, the radiation rays being detected by at leastone radiation detector; generate a preliminary image of the first objectbased on the preliminary projection values of the first object; generatecalibrated projection values of the first object based on thepreliminary image; determine a relationship between the preliminaryprojection values and the calibrated projection values; for each of theat least one radiation detector, determine a location of the radiationdetector; and determine an artifact calibration coefficientcorresponding to the radiation detector based on the relationshipbetween the preliminary projection values and the calibrated projectionvalues and the location of the radiation detector; wherein to generatethe calibrated projection values of the first object based on thepreliminary image, the at least one processor is directed to cause thesystem to: obtain a cross-section equation of the first object based onthe preliminary image of the first object; obtain a series of scanningequations, wherein each of the series of scanning equations isassociated with one of the radiation rays; and determine the calibratedprojection values of the first object based on the cross-sectionequation and the series of scanning equations of the first object. 20.The non-transitory computer readable medium of claim 19, wherein todetermine the calibrated projection values of the first object based onthe cross-section equation and the series of scanning equations of thefirst object, the at least one set of instructions directs the at leastone processor to: for each of the series of scanning equations,determine, when there is no solution satisfying both the scanningequation and the cross-section equation, the calibrated projection valueas zero; determine, when there is only one solution satisfying both thescanning equation and the cross-section equation, the calibratedprojection value as zero; and determine, when there are two solutionssatisfying both the scanning equation and the cross-section equation,the calibrated projection value based on the distance between the twosolutions.